Randomly found this 2014 Dribbble from Jamie Nicoll and it made me smile:

For context, Save For Web was a popular export function in Photoshop at the peak of its use for web design, but assigned a rather unpleasant ⌘⌥⇧S shortcut. Using it often turned your hand into a… claw of sorts.

There was a Tumblr cataloging real and humorous photos of people pressing Save For Web. You can still find parts of it on Internet Archive, and here are some choice photos:

This is funny, but I actually found it enlightening – and lightly frightening – to ask coworkers how exactly they press common shortcuts like ⌘Z, ⌘C, ⌘V, and so on. There was a lot more variety than I expected.

(My basic heuristics say: three-modifier-key shortcuts should not be assigned to anything used often.)